Data Sources and Repositories
The data produced in association with the Kinase IDG will be deposited in appropriate repositories as data is collected and quality controlled. The computer code produced will also be made available through our github page. In addition, for data types without repositories, we will use our synapse group page to distribute data.Data Downloads
We maintain downloadable collections of the data sets associated with this website:- Compounds associated with Dark Kinases (CSV format)
- NanoBRET Reagents (CSV format)
- PRM Peptides for the dark kinases (CSV format)
- Protein Interaction and Proximity Data (CSV format)
Kinase List
For reference, a complete list of the dark kinases follows, with corresponding links to information about each kinase:- ADCK1
- ADCK2
- ADCK5
- ALPK2
- ALPK3
- BCKDK
- BRSK1
- BRSK2
- CAMK1D
- CAMK1G
- CAMKK1
- CAMKK2
- CAMKV
- CDC42BPA
- CDC42BPB
- CDC42BPG
- CDK10
- CDK11A
- CDK11B
- CDK12
- CDK13
- CDK14
- CDK15
- CDK16
- CDK17
- CDK18
- CDK19
- CDK20
- CDKL1
- CDKL2
- CDKL3
- CDKL4
- CDKL5
- CLK3
- CLK4
- COQ8A
- COQ8B
- CSNK1A1L
- CSNK1G1
- CSNK1G2
- CSNK1G3
- CSNK2A2
- CSNK2A3
- DCLK3
- DSTYK
- DYRK1B
- DYRK2
- DYRK3
- DYRK4
- EEF2K
- ERN2
- HIPK1
- HIPK3
- HIPK4
- ICK
- LMTK2
- LMTK3
- LRRK1
- LTK
- MAP3K10
- MAP3K14
- MAP3K15
- MAP3K21
- MAPK15
- MAPK4
- MARK1
- MARK3
- MARK4
- MAST2
- MAST3
- MAST4
- MKNK1
- MKNK2
- NEK1
- NEK10
- NEK11
- NEK3
- NEK4
- NEK5
- NEK6
- NEK7
- NEK8
- NEK9
- NIM1K
- NRBP2
- NRK
- NUAK2
- OBSCN
- PAK3
- PAK5
- PAK6
- PAN3
- PDIK1L
- PHKG1
- PHKG2
- PI4KA
- PIK3C2B
- PIK3C2G
- PIP4K2C
- PIP5K1A
- PIP5K1B
- PIP5K1C
- PKMYT1
- PKN3
- PNCK
- POMK
- PRAG1
- PRKACB
- PRKACG
- PRKCQ
- PRPF4B
- PSKH1
- PSKH2
- PXK
- RIOK1
- RIOK2
- RIOK3
- RNASEL
- RPS6KC1
- RPS6KL1
- RSKR
- SBK1
- SBK2
- SBK3
- SCYL1
- SCYL2
- SCYL3
- SRPK3
- STK17A
- STK17B
- STK19
- STK3
- STK31
- STK32A
- STK32B
- STK32C
- STK33
- STK36
- STK38L
- STK40
- STKLD1
- TAOK1
- TAOK2
- TBCK
- TESK1
- TESK2
- TLK1
- TLK2
- TP53RK
- TSSK1B
- TSSK2
- TSSK3
- TSSK4
- TSSK6
- TTBK1
- TTBK2
- ULK4
- VRK2
- VRK3
- WEE2
- WNK2
- WNK3
Compound List
We have also compiled a set of compounds that can be used to assay the function of some of the understudied kinases:- SNS-032
- SNS-032
- BMS345541
- THZ531
- THZ531
- CAF-204
- CAF-204
- YL-206
- CAF-143
- CCT251545
- UNC-CAF-181
- AKI00000062a
- AZ-G
- BI00036838
- PFE-PKIS 10
- UNC-BE1-004
- NK-215
- LDC4297
- PFE-PKIS 8
- PA-16-0081C
- PFE-PKIS 18
- SB-245391
- SB-284851
- SGC-STK17B-1
- SGC-CLK-1
- SGC-CAMKK2-1
- SGC-CAMKK2-1
- SGC-CK2-1
- BI00048423
- AA-CS-1-002
- CAF333
- AKI00000020a
- AA-CS-3-015
NanoBRET List
We have also developed or cataloged NanoBRET assays for a wide range of the understudied kinases:- NEK6
- NIM1K
- PAK6
- TESK1
- CDK10
- CDK11A
- CDK11B
- CDK12
- CDK13
- CDK14
- CDK16
- CDK17
- CDK18
- CLK4
- CSNK2A2
- DYRK2
- LTK
- BRSK2
- CDK15
- CDK20
- CDKL1
- CDKL2
- CDKL3
- CDKL5
- CSNK1G2
- DYRK1B
- MKNK2
- NEK3
- NEK9
- RIOK2
- STK33
- PAK5
- PKN3
- STK17B
- CDK19
- DCLK3
- HIPK1
- HIPK3
- HIPK4
- MAPK4
- MARK4
- NEK4
- NEK11
- CAMK1D
- ICK
- MAP3K10
- MARK3
- NEK5
- PHKG1
- STK3
- STK32A
- STK32B
- STK38L
- DYRK3
- ERN2
- MAP3K21
- COQ8B
- CSNK1A1L
- DSTYK
- MAST3
- MAST4
- PHKG2
- SBK3
- WEE2
- NUAK2
- PKMYT1
- PRKACB
- STK17A
- TLK1
- TLK2
- PIP4K2C
- TSSK1B
- CAMK1G
- BRSK1
- NIM1K
- CSNK1G1
- CSNK1G3
- NEK6
- PAK6
- TESK1
- TTBK2
- TTBK1
- PIP5K1C