BR serine/threonine kinase 2
These figures show a summary of data collected by the cancer genome atlas for BRSK2. The mutations heatmaps shows the fraction samples with each type of genetic mutation, while the copy number variation shows the percentage of samples where a deletion or amplication was dectected. Finally, the mRNA expression tab shows the amount of mRNA detected on a log-2 scale for each cancer type. The X-axis cancer type abbreviations are described here. This summary of the cancer genome atlas (TCGA) was collated from firebrowse developed by the Broad Institute. The code used to produce these figures is available through github.
Compound Name: GW296115
Chemical Name: 3,9-dimethoxy-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Smile String: COC1=CC2=C(NC3=C2C4=C(C(NC4=O)=O)C5=C3NC6=C5C=C(OC)C=C6)C=C1
Chemical Formula: C22H15N3O4
Molecular Weight: 385.38
This compound is available through SGC-UNC.
Additional data concerning this compound can be found here.
This data stems from the differentiation of neural stem cells into fully functional neurons and glia, which requires precise regulation of diverse molecular pathways over time and space. As part of the Harvard Medical School Library of Integrated Network-based Cellular Signatures (LINCS) Program (NIH grant U54 HL127365, lincs.hms.harvard.edu), we used phospho-proteomics to assess changes during ReN VM cell differentiation. Depicted is the dark kinase of interest (black) and two reference kinases (blue and green) to aid interpretation of the values. More information on this work can be found on Synapse.
INDRA (Integrated Network and Dynamical Reasoning Assembler) is an automated model assembly system drawing from natural language processing systems and structured databases. It collects mechanistic and causal assertions, represents them in a standardized form (INDRA Statements), and assembles them into various modeling formalisms including causal graphs and dynamical models. More information on this work can be found on Github. In this particular figure, several interaction-types are depicted; physical complexes (blue), phosphorylation (black), and general up- or downregulation (green and red, respectively). Biomacromolecules are represented as squares, small molecule as circles, and biological processes and diamonds. The thickness of each line reflects a confidence score, with thicker lines higher in confidence.
Affinity Purification - Mass Spectrometry
The expression of kinases varies widely across the human tissues assayed by the GTEx project. To gain a better understanding of the kinase tissue distribution, we've created an application that describes and summarizes the expression of each dark kinase in the context of the rest of the kinome. These visualizations show a snapshot of the data associated with BRSK2. The two anatograms show the five organs where BRSK2 is most abundant. The graph summarizes the expression of the kinase across all the organ systems.
This data can further explored at our Kinase Expression Data Application.